Research old

Research Focus

Dr. Marcu’s laboratory investigates applications of fluorescence lifetime spectroscopy and imaging techniques along with other imaging modalities for the deciphering biochemical and morphological changes in biological tissue in-vitro, ex-vivo and in-vivo. The lab has also developed novel methods to process images from optical signals.

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Current Research Projects

The work in her laboratory is highly translatable and targets several clinical areas including but not limited to (a) intravascular diagnosis of cardiovascular diseases (atherosclerosis), (b) intraoperative delineation of tumor margins (brain, head and neck, breast), and (c) non-destructive assessment of engineered tissues such as cartilage, bone, vascular grafts and more.

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Image-Guided Robot Interventions

 

The overarching goal of this project is to enhance the functionality on the widely-used commercial da Vinci Surgical platform by integrating an optical diagnostic port in their robotic surgical instruments… (Read More)

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Guiding Treatment and Study of Atherosclerotic Cardiovascular Disease

 

We research the development of an intravascular bi-modal technology for diagnosis of arterial wall pathologies including rupture-prone (vulnerable) atherosclerotic plaques… (Read More)

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Imaging for Non-Destructive Assessment of Engineered Tissue

 

Our laboratory research the applicability of a multimodal tissue diagnostic platform combining optical (Time-Resolved Fluorescence Spectroscopy (TRFS)) and ultrasound backscatter microscopy (UBM) technologies for label-free, real-time, non-destructive in vitro and in vivo analysis of composition, structure and function of engineered tissue constructs… (Read More)

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Intraoperative Delineation of Tumor Resection Margins

 

Our lab is developing fluorescence lifetime techniques that have potential to analyze the brain tissue molecular makeup and to resolve distinct types of brain tumors from the surrounding normal or radiation necrosis during surgical interventions… (Read More)

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Cerenkov Radiation Activated Photodynamic Therapy (PDT)

 

Translation to the clinical setting however, has largely been inhibited by the limited penetration depth of light in tissue using traditional lasers and LEDs as light sources. Cerenkov luminescence represents a potential solution to this problem and could deliver light noninvasively to deep tissues… (Read More)

 

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