FLIm-OCT image of cartilage tissue construct

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  • In this work, multimodal FLIm-OCT is used to nondestructively monitor the heterogenous growth of engineered tissue constructs in situ in a pre-clinical mouse model.

In our latest publication, the ability of multimodal FLIm–OCT to nondestructively monitor the heterogenous growth of engineered tissue constructs in situ is demonstrated. Spatial and temporal variation of construct ECM component was detected by FLIm. OCT reveals structural defects (voids and cysts). This multimodal approach has great potential to replace costly destructive tests in the manufacturing of tissue-engineered medical products, facilitating their clinical translation.

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